General Cell Lines and Cell Cultures
ATCC Burkholderia orbicola; 385
This bacterial strain was isolated from a urinary infection. It has applications in opportunistic pathogen research.
Eurofins Discoverx Ready-to-Assay BB1 Bombesin Receptor Frozen Cells, 2 Vials of Cells. (HTS123RTA)
The Ready-to-Assay BB1 Bombesin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. bombesin, neuromedin B) based activation of NMBR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NMBR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of NMBR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay DP Prostanoid Receptor Frozen Cells, 2 Vials of Cells. (HTS091LRTA)
The Ready-to-Assay DP Prostanoid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prostaglandin D2) based activation of PTGDR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGDR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGDR, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen OT Oxytocin Receptor Stable Cell Line, 2 vials. (HTS090C)
The ChemiScreen OT Oxytocin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. oxytocin) based activation of OXTR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OXTR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OXTR, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiBrite DP Prostanoid Receptor Stable Cell Line, 2 vials. (HTS091L)
The ChemiBrite DP Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of PTGDR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGDR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGDR, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay V 1A Vasopressin Receptor Frozen Cells, 2 Vials of Cells. (HTS059RTA)
The Ready-to-Assay V 1A Vasopressin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. vasopressin) based activation of AVPR1A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR1A alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR1A, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen NOP/ORL1 Opioid Receptor Membrane Preparation, 1 vial. (HTS040M)
The ChemiScreen NOP/ORL1 Opioid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of OPRL1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen VPAC1 Receptor Membrane Preparation, 1 vial. (HTS043M)
The ChemiScreen VPAC1 Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of VIPR1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx PrecisION hTRPV1 Recombinant Stable Cell Line, 2 vials. (CYL3063)
The PrecisION hTRPV1 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying TRPV1 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses TRPV1 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
ATCC Streptomyces albidoflavus
Streptomyces albidoflavus strain ISP 5233 is a bacterial strain that is propagated aerobically.
ATCC Pfizer Pneumococcal polysaccharide powder Type 4 (d4) 10mg
Purified pneumococcal polysaccharide type 4 is manufactured by Pfizer, Inc. for small quantity distribution by ATCC. The pneumococcal powder type 4 is a component of the current 13-valent vaccine against Streptococcus pneumoniae. The pneumococcal polysaccharide type 4 can be used to assay for type-specific antibodies, research immune responses and study immunodeficiencies.